A “vulnerable” bulimic woman suffered the “most distressing” death after taking a toxic slimming aid she bought online, a court heard.
Eloise Parry, 21, died in April 2015 after taking eight diet pills containing Dinitrophenol (DNP).
Albert Huynh, 33, Bernard Rebelo, 30, and Mary Roberts, 32, all deny Miss Parry’s manslaughter.
Prosecutor Richard Barraclough QC told jurors taking the chemical is like “playing Russian roulette”.
Opening the case at Inner London Crown Court, he said “you might survive, you might not”.
Miss Parry, a student at Glyndwr University, Wrexham, started taking the chemical in pill form in February 2015, and soon became addicted.
It is alleged the group were operating from a flat in Harrow, north west London, and made the capsules which they sold online for considerable profits.
Jurors were told how the defendants bought the chemicals in drums from China and two of the defendants had consumed DNP themselves so knew of its dangers.
The defendants “cynically thwarted” authorities such as the Food Standards Agency and Interpol which tried to close down their operations, the court heard.
Describing DNP and its effects, Mr Barraclough said it was a “highly toxic substance when ingested, inhaled or absorbed through the skin”.
He added it causes weight loss by burning fat and carbohydrates, in turn causing energy to be converted into heat.
“The result is that that person’s temperature and metabolic rate all dangerously increase,” Mr Barraclough explained.
Mr Huynh from Northolt, north-west London, Mr Rebelo and Ms Roberts both from Gosport, deny two counts each of manslaughter, one count each of supplying an unsafe food, and Ms Roberts faces a single count of money laundering.
The trial continues.